The Effect Of Cd44 Expression On Drug Resistance And Cell...

Ijeoma Unachukwu PI: Dr. Kyle Murphy Fall 2014 The Effect of CD44 Expression on Drug-Resistance and Cell Migration in the Zebra Fish Xenotransplant Model Abstract Introduction Xenotransplanting is an effective tool to look at the profileration and metastisi of cancer cells. Traditionally, xenotransplant experiments have been done in mice, but for this experient we used zebra fish. Xenotransplantation in mice can be timlely and costly and often times inefficient. Zebrafish on the other hand have can reproduce quicly and have similar systems to that of humans. One of the main benefits of using zebrafish a cancer xenotransplant model is that they do not develop an adaptive immune system until 14 days after post fertilization. This makes it possible for human cancer cells to survive when they are injected into the zebrafish embryos. (Evaluating human cancer cell metastasis in zebrafish Yong Teng, Xiayang Xie, Steven Walker, David T White, Jeff S Mumm and John K Cowell).Recent papers have already proven the similarities between human and zebrafish liver tumors at a molecular level. Also, studies have created carcinogen induced neoplasms that resemble human timo rs in zebra fish and they have metastasized. In every situation, human cancer cells and tissue have survived and proliferated in zebra fish provinf that it is a comparative tumor model. Not only can xenotransplanted zebrafish can support the normal development of the host and proliferation of transplanted human melanomaShow MoreRelatedA Study On Type 2 Diabetes Essay857 Words   |  4 Pagessolution. The best solution according to Dr. Leahy lays in understanding the mechanisms of insulin resistance and beta-cell function (3). With previous research suggesting that Insulin resistance may be caused by adipose tissue inflammation, Dr. Kodama from Stanford University School of Medicine and colleagues, set out to test these hypotheses. They started their research by using an expression-based genome-wide association study (eGWAS). This approach entitles using data from previously publishedRead MoreColorectal Cancer : The Third Most Common Cancer901 Words   |  4 Pagesrates. Conventional chemotherapy efficiently targets tumor bulk, however, a small subpopulation of cells, known as cancer stem cells (CSCs), contribute to resistance to therapy, tumor regrowth and relapse. These CSCs have been shown to be responsible for the initiation and maintenance of tumors, as well as chemotherapeutic resistance and cancer recurrence. Accordingly, targeting this group of cells has become a major key to improve the treatment of CRC. Salinomycin is a polyether antibiotic usedRead MoreIs Cancer A Dangerous And Fatal Diseases?898 Words   |  4 Pagesproliferation of cells. Cancer cells’ survival, progression and metastasis are tightly associated with the cellular components. For example, when cells metastasizing, they use cell protrusion which provided by actin cytoskeleton to penetrate the extracellular matrix, they also secrete plasminogen activator to increase protease plasmin’s activity in order to penetrate the membrane. Then some of the tumor cells transfer to another tissue and form metastatic tumor. The specific functions of several cell structuresRead MoreCell Structures And Transporters Unit Assessment901 Words   |  4 PagesCell Structures and Transporters Unit Assessment Cancer is one of the most dangerous and fatal diseases, which is caused by uncontrolled growth and proliferation of cells. Cancer cells’ survival, progression and metastasis are tightly associated with the cellular components. For example, when cells metastasizing, they use cell protrusion which provided by the actin cytoskeleton to penetrate the extracellular matrix, they also secrete plasminogen activator to increase protease plasmin’s activity inRead MoreSymptoms And Treatment Of Gi Cancer Resistance Networks3430 Words   |  14 Pagesfailure. GI cancer resistance networks are in part due to interactions between parallel signaling and aberrantly expressed microRNAs (miRNAs) that collectively promote the development and survival of drug-resistant cancer stem cells (CSCs) with epithelial-to-mesenchymal transition (EMT) characteristics. The lack of understanding of resistance networks associated with this subpopulation of cells as well as reductionist single protein/pa thway targeted approaches has rendered â€Å"effective drug design† a difficult